目的 研究黃芪苷 對正常和心功能受抑制大鼠左心室心肌力學(xué)的效應(yīng)。方法 采用左心室導(dǎo)管法,測定左心室壓力 (L VP)及其微分 (dp/dt),對 iv黃芪苷 (1m g/kg)對左心室心肌力學(xué)的效應(yīng)。iv普萘洛爾 (0 .75m g/kg)抑制大鼠心功能,觀察黃芪苷 的對抗作用。結(jié)果 黃芪苷 使心率 (HR)略有減慢 ;使左室壓力上升最大速度 (dp/dtmax)明顯提高,具有正性肌力作用 ;使左室壓力下降的時間常數(shù) (T)顯著縮短,改善心臟舒張功能 ;左心室射血的張力 -時間指數(shù) (TTI)無明顯改變,表明該藥在增強(qiáng)心肌收縮力的同時并未增加心肌耗氧量。對普萘洛爾抑制心功能的大鼠,用黃芪苷 后 dp/dtmax無顯著降低,即該藥可對抗普萘洛爾抑制心肌收縮力的作用 ;T值顯著縮短,表明心臟舒張功能也有改善 ;心肌耗氧量不增加。結(jié)論 黃芪苷 可改善心臟收縮及舒張功能,可望成為一種強(qiáng)心和改善心功能的藥物

Object To study the effects of astragaloside Ⅳ, which was obtained from Astragalus membranaceus Bge., on myocardiac dynamics and cardiac function on normal and cardiac depressant rat. Methods Left ventricular pressure (LVP) and differential value of dp/dt were recorded by left ventricular catherization to observe the effect of 1 mg/kg iv astragaloside Ⅳ on normal and cardiac depressant rat induced by iv 0.75 mg/kg of Propanolol. Results Astragaloside Ⅳ decreased heart rate slightly, and showed inotropic activity by increasing dp/dtmax significantly, with improvement of cardiac diastolic function. It shortened the time constant (T) and caused no obvious change on the tension time index (TTI) in normal rat. These results suggested that astragaloside Ⅳ did not increase cardiac oxygen consumption while exerting its inotropic effect. Conclusion Astragaloside Ⅳ can improve both cardiac systolic and diastolic functions, and may be used as a candidate for the treatment of cardiac disfunction.

天津市科委21世紀(jì)青年基金資助項(xiàng)目(No.953709311)