龍膽苦苷的保肝作用研究

劉占文; 陳長勛; 金若敏; 史國慶; 宋純清; 胡之璧; LIU Zhan-wen; CHEN Chang-xun; JIN Ruo-min; SHI Guo-qing; SONG Chun-qing; HU Zhi-bi

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主辦：天津藥物研究院中國藥學(xué)會

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首頁 > 過刊瀏覽>2002年第卷第1期 >2002(1):47-50

龍膽苦苷的保肝作用研究

Studies on liver-protection and promoting bile secretion of gentiopicroside

發(fā)布日期：2015-01-07

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[關(guān)鍵詞]

[摘要]

目的研究ig 龍膽苦苷的肝保護(hù)作用及與龍膽草藥理作用的一致性。方法給動物ig 給藥,用CCl_{4、D-GlaN 造急性肝損傷模型,測定小鼠血清ALT、AST 及肝組織中谷胱甘肽過氧化物酶含量,采用麻醉大鼠,測定膽汁分泌量及膽汁成分。結(jié)果 ig 龍膽苦苷后能明顯降低CCl_{4 急性肝損傷小鼠血清ALT、AST 水平及增加肝組織中谷胱甘肽過氧化物酶活力,大鼠膽流量明顯增加,膽汁中膽紅素濃度提高。結(jié)論龍膽苦苷具有明顯肝保護(hù)作用。}}

[Key word]

[Abstract]

Object To study the liver-protection and bile promoting secretion of gentiopicroside administrated ig in rat. Methods Gentiopicroside was administrated ig to the mice with liver injury induced by CCl_{4 and D-GlaN. ALT, AST levels in serum and GSH-Px activity in liver were examined. The bile flow rate and the concentration of the main components in the bile of rats after ig administration of gentiopicroside were estimated. Results Gentiopicroside administrated ig decreased the serum ALT and AST levels, increased the liver GSH-Px activity in the mice treated with CCl_{4, promoted the secretion of bile and increased the concentration of bilirubin in the bile. Conclusion Gentiopicroside administrated ig exhibited significant liver-protection and promoting bile secretion.}}

[中圖分類號]

[基金項目]

國家“九五”攻關(guān)課題“龍膽苦苷質(zhì)量標(biāo)準(zhǔn)的規(guī)范化研究”,批準(zhǔn)號969030203