目的 熊果酸為山楂所含三萜類物質(zhì)的主要成分,金絲桃苷是山楂黃酮的重要組分,觀察其降血脂作用,確定以這兩種物質(zhì)作為山楂藥材質(zhì)量的控制指標(biāo)。方法 以75%蛋黃乳和400mg/kg Triton-WR1339ip 復(fù)制小鼠高脂血癥模型,分別給予金絲桃苷50,15mg/kg,熊果酸80,40mg/kg,酶反應(yīng)終點(diǎn)法測(cè)定小鼠血清TCH、TG、HDL 值。結(jié)果 兩種化合物均顯著降低小鼠血清TCH 和升高HDL/TCH 的比值。結(jié)論 金絲桃苷和熊果酸均有明顯降低高脂模型小鼠血清TCH 的作用,其作用與其升高HDL 百分比值和SOD 活性有關(guān)。

Object To study the antihyperlipidemia effect of ursolic acid and hyperoside from hawthorn and to establish quality control standard for hawthorn. Methods Two animal models of hyperlipidemia were made in mice with 75% yolk and Triton-WR 1339400mg/kg ip respectively. Then the animals were administrated with hyperoside or ursolic acid extracted from hawthorn in two doses. The total cholestrol (TCH), triglyceride (TG), high density lipoprotein (HDL) and superoxide dismutase (SOD) activities in serum were measured. Results In comparison with control groups, TCH levels in all the dose groups were significantly decreased, while HDL and SOD activity increased. Conclusion Both hyperoside and ursolic acid have the effects regulating serum lipids and could be used in quality control of hawthorn.

國(guó)家“九五”重點(diǎn)攻關(guān)課題