目的將五仁醇制成固體分散體,提高五仁醇中有效成分的體外溶出度.方法采用直接將載體材料溶于五仁醇提取液,然后除去溶劑的方法制備了多種五仁醇固體分散體,以五味子甲素為指標(biāo)成分,研究并比較了它們的表觀溶解度和體外溶出度.結(jié)果配比為1:3的五仁醇-聚乙烯吡咯烷酮K 30(PVP K 30)固體分散體中有效成分的表觀溶解度比五仁醇膠囊內(nèi)容物顯著提高,達(dá)到5.06μg/mL(水);溶出介質(zhì)(水)中分散(包括溶解)的小于0.22μm的藥物高達(dá)43.2%.結(jié)論五仁醇-PVP K 30固體分散體能明顯提高五仁醇中有效成分的表觀溶解度和體外溶出度.

Objective To prepare Wurenchun solid dispersion of alcohol extracts ofFructus Schisandrae Chinensisso as to improve the dissolution of its active compound in vitro.Methods The Wurenchun solid dispersions were prepared with various carriers and drug/carrier ratios by mixing the carrier in alcohol extractive solution of FSC directly,and the apparent solubility and dissolution of deoxyschisandrin in them were tested and compared.Results The apparent solubility and dissolution of deo-xyschisandrin of Wurenchun solid dispersion(extracts:polyvinylpyrrolidone(PVP)K30=1:3)were increased remarkably to5.06μg/mLand 43.2% in water individually,including dispersed and dissolved drug whose particle size is below 0.22弘m,compared with that of the self-prepared Wurenchun capsules.Conclusion Wurenchun solid dispersion made of PVP K30 can remarkably enhance apparent solubility and dissolution of the active compound in vitro.