app)增加了1.36倍,與對(duì)照組相比具有顯著性差異(P<0.05);0.3、0.4、0.5、0.7 mg/mL的冰片使黃芩苷Papp分別增加了1.35、1.43、1.51、3.47倍,0.2、0.3、0.4、0.5、0.7 mg/mL的熊去氧膽酸使黃芩苷Papp分別增加了1.19、2.25、1.24、0.35、0.68倍,與對(duì)照組相比均具有非常顯著性差異(P<0.01)。結(jié)論 0.2、0.3、0.4、0.5、0.7 mg/mL的冰片、熊去氧膽酸能夠顯著增大黃芩苷的Papp,且對(duì)角膜無(wú)刺激性。;Abstract: Objective To investigate the effects of borneol and ursodesoxycholic acid on the corneal permeability of baicalin in vitro, and to discuss their application in ocular preparation. Methods The effects of borneol and ursodesoxycholic acid with different concentration on the corneal permeability of baicalin were investigated in vitro using the isolated corneal penetration technology. Results Borneol (0.2 mg/mL) could significantly increase the apparent permeability (Papp) of baicalin in 1.36-fold compared with the control group (P < 0.05). Borneol (0.3, 0.4, 0.5, and 0.7 mg/mL) could increase the Papp of baicalin in 1.35-, 1.43-, 1.51-, and 3.47-folds, respectively, and ursodesoxycholic acid (0.2, 0.3, 0.4, 0.5, and 0.7 mg/mL) could significantly increase the Papp of baicalin in 1.19-, 2.25-, 1.24-, 0.35-, and 0.68-folds, respectively compared with the control group (P < 0.01). Conclusion Borneol and ursodesoxycholic acid (0.2, 0.3, 0.4, 0.5, and 0.7 mg/mL) could significantly increase the Papp of baicalin without stimulation on rabbit cornea."/>

醉酒后少妇被疯狂内射视频,一本色道久久综合一,在线天堂新版资源www在线下载,中文字幕乱人伦高清视频,中字幕视频在线永久在线观看免费

首頁(yè) > 過(guò)刊瀏覽>2013年第44卷第2期 >2013,44(2):153-157. DOI:10.7501/j.issn.0253-2670.2013.02.007
上一篇 | 下一篇

冰片和熊去氧膽酸對(duì)黃芩苷角膜透過(guò)性的影響

Effects of borneol and ursodesoxycholic acid on corneal permeability of baicalin

發(fā)布日期:
您是第位訪問(wèn)者
中草藥 ® 2025 版權(quán)所有
技術(shù)支持:北京勤云科技發(fā)展有限公司
津備案:津ICP備13000267號(hào) 互聯(lián)網(wǎng)藥品信息服務(wù)資格證書(shū)編號(hào):(津)-非經(jīng)營(yíng)性-2015-0031