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[摘要]
目的 研究高山紅景天Rhodiola sachalinensis干燥根及根莖的化學成分。方法 利用反復硅膠柱色譜、中壓柱色譜及半制備液相色譜等方法分離純化;通過核磁共振譜、質譜等光譜數據鑒定化合物結構。結果 分離得到18個化合物,分別鑒定為沒食子酸(1)、對羥基苯甲酸(2)、紅景天苷(3)、苯甲醇-O-β-D-吡喃葡萄糖苷(4)、苯乙醇-8-O-β-D-吡喃葡萄糖苷(5)、苯丙烯醇-O-β-D-吡喃葡萄糖苷(6)、(2E, 4R)-4, 7-二羥基-3, 7-二甲基-2-烯基-β-D-吡喃葡萄糖苷(高山紅景天醇,7)、槲皮素(8)、槲皮素-3-O-β-D-吡喃葡萄糖苷(9)、山柰酚(10)、山柰酚-7-O-α-L-吡喃鼠李糖苷(11)、山柰酚-7-O-β-D-吡喃葡萄糖苷(12)、山柰酚-3-O-α-L-鼠李糖苷(13)、山柰酚-3-O-β-D-吡喃葡萄糖-7-O-α-L-鼠李糖苷(14)、小麥黃素(15)、3, 5, 7, 5′-四羥基-4′-甲氧基黃酮(檉柳亭,16)、草質素-7-O-α-L-吡喃鼠李糖苷(17)、草質素-3-O-β-D-吡喃葡萄糖-7-O-α-L-鼠李糖苷(18)。結論 化合物9、12、16為首次從紅景天屬植物中分離得到,化合物2、7、8、14、18為首次從本植物中分離得到。
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[Abstract]
Objective To investigate the chemical constituents from the roots and rhizomes of Rhodiola sachalinensis. Methods The chemical constituents were isolated by repeated silica gel chromatography, medium pressure column chromatography, and semi-preparative liquid chromatography, and their structures were elucidated by chemical properties and spectroscopic analyses. Results Eighteen compounds were isolated and identified to be gallic acid (1), p-hydroxybenzoic acid (2), salidroside (3), benzyl-O-β-D-glucopyranodide (4), phenylethyl-8-O-β-D-glucopyranodide (5), cinnamyl-β-D-glucopyranoside (6), sachalinol (7), quercetin (8), quercetin-3-O-β-D-glucopyranoside (9), kaempferol (10), kaemferol-7-O-α-L-rhamnopyranoside (11), kaempferol- 7-O-β-D-glucopyranoside (12), kaemnpferol-3-O-α-L-rhamnoside (13), kaempferol-3-O-β-D-glucopyranoside-7-O-α-L-rhamnoside (14), tricin (15), tamarixetin (16), herbacetin-7-O-α-L-rhamnoside (17), and herbacetin-3-O-β-D-glucopyranoside-7-O-α-L- rhamnoside (18). Conclusion Compounds 9, 12, and 16 are obtained from the plants in Rhodiola L. for the first time. Compounds 2, 7, 8, 14, and 18 are obtained from this plant for the first time.
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