目的 研究天麻藥材-飲片-浸膏-配方顆粒這一制備過(guò)程中氣味的變化與相關(guān)性，嘗試引入新的制劑工藝整體評(píng)價(jià)指標(biāo)，探討符合中醫(yī)藥整體觀的中藥配方顆粒制備工藝。方法 利用電子鼻技術(shù)采集各樣品的氣味數(shù)據(jù)，通過(guò)主成分分析（PCA）、判別因子分析（DFA）和統(tǒng)計(jì)質(zhì)量控制分析（SQCA）等統(tǒng)計(jì)學(xué)方法對(duì)特征數(shù)據(jù)進(jìn)行分析。結(jié)果 天麻藥材-飲片-浸膏這一制備過(guò)程中，天麻氣味損失較??；而浸膏-配方顆粒這一過(guò)程中氣味損失較大，提示按現(xiàn)有化學(xué)藥模式評(píng)價(jià)中藥配方顆粒工藝雖然可行，但與符合中醫(yī)藥整體觀的氣味指標(biāo)評(píng)價(jià)結(jié)果有差異。結(jié)論 電子鼻技術(shù)可用于天麻樣品（不同的形式）氣味信息數(shù)據(jù)的采集，通過(guò)不同的模型進(jìn)行數(shù)據(jù)分析后，可從不同天麻樣品的氣味之間找出差異與相關(guān)性，氣味指標(biāo)可作為天麻配方顆粒制劑工藝的整體評(píng)價(jià)指標(biāo)。

Objective To study the change and correlation of odour during the preparation process of Gastrodiae Rhizoma-pieces- extract-formula granules. A new overall evaluation index of preparation process was introduced to investigate the preparation process of Chinese medicinal granules, which was in line with the overall concept of traditional Chinese medicine (TCM). Methods The odour data of all samples were collected using an electronic nose technology. Then the characteristic data were analyzed through statistical methods, such as principal component analysis (PCA), discriminant factor analysis (DFA), and statistical quality control analysis (SQCA). Results The odour loss was very small during the preparation process of herb-pieces-extract; while the odour loss during extract-formula granules process was bigger. This prompted that it was feasible to evaluate the technology of TCM formula particles according to the existing mode of chemical drugs, but it was different from the evaluation results using the overall concept of TCM as evaluation index. Conclusion The electronic nose technology could be used for collecting odour data of Gastrodiae Rhizoma samples in different forms. Through data analysis with various models, the difference and correlation among different odour of Gastrodiae Rhizoma samples could be identified. The odour could be used as the overall evaluation index during the preparation process of Gastrodiae Rhizoma Formula Granule.

國(guó)家“十二五”科技支撐計(jì)劃資助（2012BAI29B11）；中央高?；究蒲袠I(yè)務(wù)費(fèi)專項(xiàng)資金資助（SWJTU12CX051，SWJTU11ZT26）