目的 對(duì)薄荷Mentha haplocalyx的化學(xué)成分進(jìn)行研究。方法 采用多種柱色譜技術(shù)進(jìn)行分離純化，并通過波譜分析方法鑒定化合物的結(jié)構(gòu)。結(jié)果 從薄荷乙醇提取物中分離得到了11個(gè)化合物，分別鑒定為薄荷木酚素（1）、5-羥基-6, 7, 8, 4′-四甲氧基黃酮（2）、樺木酸（3）、橙皮素-7-O-β-D-葡萄糖苷（4）、龍膽酸-5-O-β-D-(6′-水楊?；?-葡萄糖苷（5）、蒙花苷（6）、刺槐素（7）、5-羥基-6, 7, 8, 3′, 4′-五甲氧基黃酮（8）、5, 6, 4′-三羥基-7, 8-二甲氧基黃酮（9）、田薊苷（10）、藿香苷（11）。結(jié)論 化合物1為新的木酚素類化合物，命名為薄荷木酚素；化合物2為新天然產(chǎn)物；化合物4為首次從唇形科中分離得到；化合物3、5為首次從薄荷屬中分離得到。

Objective To study the chemical constituents from Mentha haplocalyx. Methods Compounds were isolated and purified by various chromatographic techniques, and their structures were identified by spectral analysis. Results Eleven compounds were isolated and identified, including menthalignin (1), 5-hydroxy-6, 7, 8, 4′-tetramethoxyflavone (2), betulinic acid (3), hesperetin 7-O-β-D-glucopyranoside (4), gentisic acid 5-O-β-D-(6′-salicylyl)-glucopyranoside (5), linarin (6), acatin (7), 5-hydroxy-6, 7, 8, 3′, 4′-pentamethoxyflavone (8), 5, 6, 4′-trihydroxy-7, 8-dimethoxyflavone (9), tilianin (10), and agastachoside (11). Conclusion Compound 1 is a new lignan named menthalignan; compound 2 is a new natural product; compound 4 is isolated from the plants in Labiatae for the first time, and compounds 3 and 5 are firstly reported in the plants of Mentha L.

國(guó)家“十二五”支撐計(jì)劃項(xiàng)目（2011BA104B06）