目的 研究洋金花Datura metel 葉的化學(xué)成分。方法 應(yīng)用乙醇提取洋金花葉，采用硅膠、AB-8大孔吸附樹脂、ODS和Sephadex LH-20等柱色譜以及制備液相等技術(shù)分離純化化合物，根據(jù)理化性質(zhì)及波譜數(shù)據(jù)進(jìn)行結(jié)構(gòu)鑒定。結(jié)果 從洋金花葉中分離得到14個(gè)化合物，分別鑒定為naphthisoxazol A（1）、刺龍芽糖苷I（2）、L-色氨酸（3）、槲皮素3-O-2-(E-咖啡酸)-α-L-阿拉伯糖-(1→2)-β-D-吡喃葡萄糖-7-O-β-D-葡萄糖苷（4）、正丁基-O-α-D-呋喃果糖苷（5）、金線蓮堿（6）、二氫催吐蘿芙木醇-O-β-D-葡萄糖苷（7）、(6S, 7E, 9S)-9-[(β-D-glucopyranosyl)-oxy] megastigma-4, 7-dien-3-one（8）、山柰酚-3, 7-二- O-β-D-吡喃葡萄糖苷（9）、山柰酚-7-O-β-D-葡萄糖苷（10）、槲皮素-7-O-葡萄糖苷（11）、(6S, 9R)-6-羥基-3-酮-α-紫羅蘭醇-9-O-β-D-葡萄吡喃糖苷（12）、豆甾醇（13）、豆甾醇-3-O-β-D-葡萄糖苷（14）。結(jié)論 化合物1～8為首次從茄科中分離得到。

Objective To study the chemical constituents in the leaves of Datura metel. Methods The chemical constituents of ethanol extract from the leaves of D. metel were isolated and purified by chromatography over silica gel, AB-8 macroperous resin, ODS, Sephadex LH-20 columns, and RP-preparative HPLC. The structures were elucidated on the basis of physicochemical properties and spectral data analyses. Results Forteen compounds were isolated and identified as naphthisoxazol A (1), congmuyaglyeoside I (2), L-tryptophan (3), quercetin3-O-2-(E-caffeoyl)-α-larabinopyranosyl-(1→2)-β-D-glucopyranoside-7-O-β-D-glucoside (4), n-butyl- O-α-D-fructofuranosidase (5), anoectochine (6), dihydrovomifoliol-O-β-D-glucoside (7), (6S, 7E, 9S)-9-[(β-D-glucopyranosyl)-oxy] megastigma-4, 7-dien-3-one (8), kaepmferol-3, 7-di-O-β-D-glucopyranoside (9), kaempferol-7-O-β-D-glucoside (10), quercetin-7- O-glucoside (11), (6S, 9R)-6-hydroxy-3-ketone-α-violet-grape alcohol-9-O-β-D-glucopyranoside (12), stigmasterol (13), and stigmasterol-3-O-β-D-glucoside (14). Conclusion Compounds 1—8 are firstly found in the plants of Solanaceae.