目的 研究蓍草Achillea alpina 地上部分的化學(xué)成分。方法 利用多種柱色譜手段進(jìn)行分離與純化，通過理化性質(zhì)和波譜數(shù)據(jù)鑒定化合物的結(jié)構(gòu)。結(jié)果 從蓍草乙醇提取物的氯仿萃取部分分離得到11個(gè)化合物，分別鑒定為表木栓醇（1）、菠菜甾醇（2）、β-谷甾醇（3）、5, 6-epoxy-24(R)-methylcholesta-7, 22-dien-3β-ol（4）、β-胡蘿卜苷（5）、schensianol A（6）、negunfurol（7）、(3S, 5S, 8R)-3, 5-dihydroxymegastigma-6, 7-dien-9-one（8）、saropeptate（9）、(＋)-丁香脂素（10）、(±)-落葉松樹脂醇（11）。結(jié)論 所有化合物均為首次從該植物中分離得到，其中化合物1、2、4、6～11為首次從該屬植物中分離得到。

Objective To investigate the chemical constituents from the aerial parts of Achillea alpina. Methods The compounds were isolated and purified by various chromatographic techniques and their structures were characterized on the basis of physicochemical properties and their spectral analyses. Results Eleven compounds were isolated. Their structures were identified as epifriedelanol (1), spinasterol (2), β-sitosterol (3), 5, 6-epoxy-24(R)-methylcholesta-7, 22-dien-3β-ol (4), β-daucosterol (5), schensianol A (6), negunfurol (7), (3S, 5S, 8R)-3, 5-dihydroxymegastigma-6, 7-dien-9-one (8), saropeptate (9), (+)-syringaresinol (10), and (±)-lariciresinol (11). Conclusion All the compounds are isolated from the aerial parts of A. alpina for the first time, and compounds 1, 2, 4, 6—11 are reported to obtain from the plants in Achillea L. for the first time.

國家“十一五”規(guī)劃重大科技專項(xiàng)——先導(dǎo)化合物的發(fā)現(xiàn)與優(yōu)化技術(shù)平臺(tái)（2009ZX09301-011）；國家自然科學(xué)基金資助項(xiàng)目（81273401）；科技部“重大新藥創(chuàng)制”重大專項(xiàng)公共資源平臺(tái)“面向新藥發(fā)現(xiàn)的數(shù)字化中藥化學(xué)成分庫”（2011ZX09307-002-01）