目的 研究黃精Polygonatum sibiricum根莖的化學成分。方法 運用HP-20大孔吸附樹脂、硅膠、ODS和Sephadex LH-20等柱色譜以及反相制備型HPLC等各種現(xiàn)代色譜分離技術進行系統(tǒng)地分離純化，根據(jù)化合物的光譜數(shù)據(jù)和理化性質進行結構鑒定。結果 從黃精根莖95%乙醇提取物中分離得到5個化合物，分別鑒定為黃精新木脂素苷A（1）、（+）-異落葉松脂素-9'-O-β-D-葡萄糖苷（2）、反式-N-p-香豆?；野罚?b>3）、3-（4-羥基苯基）-N-[2-（4-羥基苯基）-2-甲氧基乙基]丙烯酰胺（4）、3-（4-羥基-3-甲氧基苯基）-N-[2-（4-羥基苯基）-2-甲氧基乙基]丙烯酰胺（5）。結論 化合物1為1個新的苯駢呋喃型木脂素，命名為黃精新木脂素苷A，化合物2～5為首次從該植物中分離得到。

Objective To isolate and identify the chemical constituents from the rhizomes of Polygonatum sibiricum. Methods The compounds were isolated and purified by various modern chromatographies, and their structures were identified by physiochemical properties and spectroscopic data. Results Five compounds were isolated from the EtOH extract of the rhizomes of P. sibiricum, which were elucidated as polygonneolignanoside A (1), (+)-isolariciresinol-9'-O-β-D-glucopyranoside (2), trans-N-p-coumaroyltramine (3), 3-(4-hydroxyphenyl)-N-[2-(4-hydroxyphenyl)-2-methoxyethyl]acrylamide (4), 3-(4-hydroxy-3-methoxyphenyl)-N-[2-(4-hydroxyphenyl)-2-methoxyethyl]acrylamide (5). Conclusion Among them, compound 1 was a new benzofuran lignan, and compounds 2-5 were isolated from this plant for the first time.

國家自然科學基金資助項目（21602047）；南陽理工學院河南省張仲景方藥與免疫調節(jié)重點實驗室開放課題（KFKT2018-2）；河南省高等學校青年骨干教師資助計劃（2017GGJS-081）