目的 對(duì)胡蘆巴Trigonella foenum-graecum的化學(xué)成分進(jìn)行研究。方法 運(yùn)用Sephadex LH-20凝膠、硅膠柱色譜、半制備高效液相色譜等多種色譜技術(shù)進(jìn)行分離和純化，并通過(guò)其理化性質(zhì)和NMR數(shù)據(jù)綜合分析，鑒定化合物結(jié)構(gòu)。結(jié)果 從胡蘆巴乙醇提取物中得到6個(gè)甾體皂苷類和黃酮類化合物，分別為22-甲氧基-胡蘆巴皂苷IIb（1）、芰脫皂苷元（2）、薯蕷皂苷元（3）、木犀草素（4）、木犀草苷（5）、木犀草素-7-O-蕓香糖苷（6）。結(jié)論 化合物1為新化合物，化合物5和6是從該植物中首次分離得到。

Objective To research the chemical constituents from Trigonella foenum-graecum. Methods The chemical constituents were separated and purified by sephadex LH-20, silica gel, semi-prepared HPLC and other chromatography techniques. Their structures were elucidated by their physicochemical properties and NMR data. Results Six steroidal saponins and flavonoids (1-6) were isolated from the ethanol extracts of T. foenum-graecum and identified as 22-methoxy-trigoneoside IIb (1), gitogenin (2), diosgenin (3), luteolin (4), cynaroside (5), and luteolin-7-O-rutinoside (6). Conclusion Compound 1 is a new compound, and compounds 5 and 6 are obtained for the first time from T. foenum-graecum.

天津市自然科學(xué)基金重點(diǎn)項(xiàng)目（16JCZDJC32600）；中國(guó)博士后基金資助項(xiàng)目（2016M591399）