2019年12月我國湖北武漢爆發(fā)的新型冠狀病毒（SARS-CoV-2）引起的肺炎（COVID-19）與2002年嚴(yán)重急性呼吸綜合征（SARS）、2012年中東呼吸綜合征（MERS）均屬于冠狀病毒引起的傳染性疾病。根據(jù)對(duì)SARS和MERS等傳染病的認(rèn)識(shí)，許多患者和醫(yī)護(hù)人員在疫情期間、疫情之后均會(huì)產(chǎn)生抑郁、焦慮等緊張情緒，尤其疫后幸存者患創(chuàng)傷后應(yīng)激障礙（PTSD）的幾率會(huì)大大增高；COVID-19疫情期間和疫后也會(huì)出現(xiàn)類似情況。因此，緩解災(zāi)難時(shí)感染患者、一線醫(yī)護(hù)人員、隔離人員等人群的緊張情緒，盡可能地降低COVID-19疫后PTSD發(fā)病率，也是防控此次疫情的一項(xiàng)重要任務(wù)。中醫(yī)藥治療情感類疾病有獨(dú)特優(yōu)勢(shì)，從中醫(yī)理論角度認(rèn)識(shí)PTSD的病因病機(jī)，尋找治療PTSD的有效方法，將會(huì)對(duì)治療疫后幸存者的PTSD有所幫助。通過對(duì)治療PTSD相關(guān)中藥的研究進(jìn)行匯總和對(duì)比，發(fā)現(xiàn)疏肝解郁方四逆散在治療PTSD方面有潛在價(jià)值。因此，四逆散可作為COVID-19疫情期間緩解患者及相關(guān)人員的抑郁和焦慮癥狀，以及疫情之后治療PTSD的首選基礎(chǔ)方藥，以期從心理精神方面幫助戰(zhàn)勝COVID-19。

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Wuhan, Hubei Province in December 2019, with severe acute respiratory syndrome (SARS) in 2002 and Middle East respiratory syndrome (MERS) in 2012 are all infectious diseases caused by coronavirus. According to the knowledge of infectious diseases such as SARS and MERS, many patients and health care workers suffered from depression and anxiety during and after the epidemic. In particular, post-epidemic survivors were more likely to suffer from post-traumatic stress disorder (PTSD). Similar conditions could be occurred during and after COVID-19. Therefore, it is also an important task to reduce the prevalence of PTSD after COVID-19 as much as possible and to relieve the tension of infected patients, first-line medical staff, quarantine personnel and so on. Traditional Chinese medicine has unique advantages in the treatment of emotional diseases. Understanding the etiology and pathogenesis of PTSD by theory of traditional Chinese medicine and looking for effective methods to treat PTSD will be helpful to treat PTSD of survivors after COVID-19. It is found that Sini Powder has potential value in the treatment of PTSD by the summary and comparison of the research on traditional Chinese medicine related to the treatment of PTSD. We hope to overcome this epidemic psychologically and spiritually. Therefore, it is considered that Sini Powder can be used as the first choice for relieving emotional diseases of related patients during COVID-19 and treating PTSD of survivors after COVID-19.

R285

國家自然科學(xué)基金資助項(xiàng)目（81460611）；2020年度甘肅省重大疾病分子醫(yī)學(xué)與中醫(yī)藥防治研究重點(diǎn)實(shí)驗(yàn)室新型冠狀病毒防治研究專項(xiàng)開放基金（FZYX20-10）