目的 對(duì)地椒Thymus quinquecostatus化學(xué)成分進(jìn)行研究，以期發(fā)現(xiàn)新化合物。方法 采用色譜硅膠、AB-8大孔樹(shù)脂、Sephadex LH-20凝膠色譜、ODS反相色譜等多種技術(shù)進(jìn)行分離純化，運(yùn)用質(zhì)譜、核磁共振譜等方法進(jìn)行化合物結(jié)構(gòu)鑒定。結(jié)果 從地椒醋酸乙酯部位分離得到2個(gè)化合物，分別鑒定為6-羥基-11-甲基-12-羥甲基萘并[2，3-β]呋喃-1，4-二酮（1）、2-羥基-4-異丙基-5-甲基苯-O-β-D-葡萄糖苷（2）。結(jié)論 化合物1、2為新化合物，分別命名為地椒醌A、地椒苷A。

Objective To study the chemical components of Thymus quinquecostatus in order to find new compounds. Methods The constituents were separated by column chromatographic methods of silica gel, AB-8 resin, Sephadex LH-20 and ODS column. The structures were elucidated by MS and NMR analyses. Results Two compounds were isolated and identified as 6-hydroxy-11-methyl-12-hydroxymethyl naphtho[2,3-β] furan-1,4-dione (1) and 2-hydroxy-4-isopropyl-5-methylbenzene-O-β-D-glucopyranoside (2). Conclusion Compounds 1 and 2 are new compounds, named quinquequinone A and quinqueside A, respectively.

R284.1

國(guó)家自然科學(xué)基金資助項(xiàng)目（81760769）；寧夏回族自治區(qū)重點(diǎn)研發(fā)計(jì)劃（2018BEG03016）；北京中醫(yī)藥大學(xué)青年教師項(xiàng)目（1000061222118）