目的 以二至丸為研究對(duì)象，探索中藥丸劑熱風(fēng)干燥過程溫度變化規(guī)律，為提高丸劑干燥效率及干燥均勻性提供理論依據(jù)。方法 基于COMSOL Multiphysics建立傳熱傳質(zhì)模型模擬二至丸層在無孔底及篩孔底2種干燥盤不同溫度干燥過程溫度分布并進(jìn)行求解；研究了二至丸層在60、80、100℃熱風(fēng)溫度下干燥過程，并通過Fick第2定律平板模型計(jì)算二至丸水分有效擴(kuò)散系數(shù)（D_eff）；采用探針溫度傳感器監(jiān)測(cè)二至丸層干燥過程中間表面及內(nèi)部溫度變化進(jìn)行干燥模型驗(yàn)證。結(jié)果 不同熱風(fēng)溫度干燥過程中二至丸層表面及內(nèi)部溫度呈現(xiàn)先劇烈上升后緩慢上升的趨勢(shì)，二至丸層無孔底干燥模型及篩孔底干燥模型內(nèi)部溫度分別為55.3～56.0℃、57.5～57.7℃，使用篩孔底干燥盤可提高干燥溫度均勻性；2種模型實(shí)驗(yàn)得到水分D_eff分別為0.76×10^-7～2.82×10^-7 m²/s、1.15×10^-7～3.94×10^-7 m²/s；實(shí)驗(yàn)結(jié)果驗(yàn)證模型在一定干燥溫度范圍內(nèi)能夠較好反映二至丸層干燥過程溫度變化規(guī)律。結(jié)論 通過可靠的二至丸層熱風(fēng)干燥模型直觀反映干燥過程溫度變化情況，該研究為二至丸干燥工藝優(yōu)化提供參考。

Objective To explore the law of temperature change in hot air drying process, and provide a theoretical basis for improving the drying efficiency and uniformity of Erzhi Pills (EP). Methods Heat and mass transfer models were established to simulate the temperature distribution of the drying process of EP with no hole bottom and screen hole bottom based on COMSOL Multiphysics. The drying process of EP layer at 60, 80 and 100℃ was studied. The effective water diffusion coefficient (D_eff) of EP layer was calculated by Fick's second law plate model. A probe temperature sensor was used to monitor the temperature changes of the intermediate surface and interior of EP layer during the drying process to verify the drying model. Results The surface and internal temperature of EP layer showed a trend of first sharp rise and then slow rise in the drying process of different hot air temperature. The inner temperature range of the drying model with no hole bottom and screen hole bottom was 55.3-56.0℃ and 57.5-57.7℃ respectively. The uniformity of drying temperature of EP can be improved by using drying plate with screen hole. The D_eff range of the two model experiments were 0.76×10^-7-2.82×10^-7 m²/s and 1.15×10^-7-3.94×10^-7 m²/s, respectively. The experimental results showed that the model could well reflect the temperature variation of EP layer drying process within a certain drying temperature range. Conclusion The change of drying temperature was directly reflected through the reliable hot air drying model of EP layer. The study provides reference for the optimization of EP drying process.

R283.6

國(guó)家自然科學(xué)基金資助項(xiàng)目（81760716）；江西省自然科學(xué)基金資助項(xiàng)目（20171BAB215065）