中西藥聯(lián)合使用在臨床上是常見的。環(huán)丙沙星是治療感染性疾病最常用的氟喹諾酮類藥物之一，為提高感染性疾病的治療效果或應(yīng)對同時患多種疾病的患者，環(huán)丙沙星與一種或多種中藥合并使用的現(xiàn)象較為普遍。中藥與環(huán)丙沙星聯(lián)用產(chǎn)生的中藥-藥物相互作用（herb-drug interaction，HDI）可能起到增效減毒的積極作用，也可能導(dǎo)致治療失敗或者發(fā)生不良反應(yīng)。環(huán)丙沙星在體內(nèi)的吸收（absorption，A）、分布（distribution，D）、代謝（metabolism，M）、排泄（excretion，E）等過程，是發(fā)生HDI的主要環(huán)節(jié)。藥物代謝酶和轉(zhuǎn)運(yùn)體對環(huán)丙沙星ADME過程的影響近年來備受關(guān)注。因此，分別從藥物代謝酶、轉(zhuǎn)運(yùn)體角度對常用中藥與環(huán)丙沙星之間的直接/潛在相互作用及其作用機(jī)制進(jìn)行綜述，以期從藥動學(xué)方面為環(huán)丙沙星與中藥的臨床合理使用提供依據(jù)。

The combination of Chinese and Western medicine is common in clinical practice. Ciprofloxacin is one of the most commonly used fluoroquinolones for the treatment of infectious diseases. In order to improve the therapeutic effect of infectious diseases or cope with patients with multiple diseases at the same time, the combination of ciprofloxacin with one or more traditional Chinese medicines is more common. The herb-drug interactions produced by the combination of Chinese materia medica and ciprofloxacin may play an active role in increasing efficacy and reducing toxicity, and may also lead to treatment failure or adverse reactions. The herb-drug interaction mechanisms will occur in the course of absorption (A), distribution (D), metabolism (M), and excretion (E). The effects of drug-metabolizing enzymes and transporters on the ADME process of ciprofloxacin have received much attention in recent years. Therefore, this paper reviews the potential interaction between common Chinese medicine and ciprofloxacin from the perspective of drug-metabolizing enzymes and transporters. It is expected to provide the basis on the rational use of ciprofloxacin and Chinese materia medica.

R285.62

天津市科技計劃項目（17ZXXYSY00060）；天津市自然科學(xué)基金項目（18JCQNJC83800）；天津市衛(wèi)計委項目（2017144）；國家科技部“十三五”重大新藥創(chuàng)制項目（2018ZX09734-002）；國家自然科學(xué)基金資助項目（81703861）