植物來(lái)源的細(xì)胞外囊泡（plant-derived extracellular vesicles，PDEVs）是植物細(xì)胞釋放的納米級(jí)囊泡，內(nèi)含蛋白質(zhì)、脂質(zhì)、核酸等生物活性物質(zhì)，不僅參與機(jī)體生理病理過(guò)程的調(diào)控，如跨界通訊、細(xì)胞增殖分化、免疫調(diào)節(jié)和炎癥反應(yīng)等，還可克服生物屏障作為藥物載體靶向病變部位，對(duì)疾病的轉(zhuǎn)歸起到關(guān)鍵作用。隨著對(duì)PDEVs研究的深入，其在腸肝疾病防治的應(yīng)用潛力逐漸顯現(xiàn)。然而關(guān)于PDEVs如何通過(guò)腸-肝軸發(fā)揮治療作用的潛在機(jī)制尚未明確，鑒于PDEVs具備良好的自然靶向性、生物相容性等突出優(yōu)勢(shì)，從腸-肝軸的角度切入，在腸道、肝臟及二者之間相互調(diào)節(jié)和通信層面上對(duì)PDEVs防治腸肝疾病的分子作用機(jī)制進(jìn)行總結(jié)探討，為PDEVs治療腸肝疾病的研究提供新的思路與方法。

Plant-derived extracellular vesicles (PDEVs) are nano-sized vesicles released by plant cells, which contain protein, lipids, nucleic acids and other bioactive substances. PDEVs not only participate in the regulation of physiological and pathological processes of the body, such as cross-border communication, cell proliferation and differentiation, immune regulation, and inflammatory reaction but also can overcome the biological barrier as a drug carrier to target the lesion and play a key role in prognosis of the disease. With the in-depth study of PDEVs, their application potential in prevention and treatment of intestinal and liver diseases has gradually emerged. However, the potential mechanism of how PDEVs can play a therapeutic role through the intestinal-hepatic axis is not clear. Given PDEVs’ outstanding advantages such as good natural targeting and biocompatibility, in this paper, the molecular mechanism of PDEVs in preventing and treating intestinal-hepatic disease is summarized and discussed from perspective of intestinal-hepatic axis, to provide new ideas and methods for research of PDEVs in treating intestinal-hepatic disease.

R285

國(guó)家自然科學(xué)基金資助項(xiàng)目（82474217）;濟(jì)南市“新高校20條”資助項(xiàng)目（202333018）