黑色素瘤是高度易于轉(zhuǎn)移的腫瘤之一，其主要的轉(zhuǎn)移器官有肺、淋巴結(jié)、腦等。黑色素瘤的轉(zhuǎn)移與上皮-間質(zhì)轉(zhuǎn)化（epithelial-mesenchymal transition，EMT）、代謝重編程及免疫微環(huán)境密切相關(guān)。EMT使黑色素瘤細(xì)胞變得更具侵襲性，同時伴隨代謝重編程，為細(xì)胞提供能量支持，助長免疫逃逸，促使腫瘤發(fā)展和轉(zhuǎn)移。中藥可通過抑制EMT過程、調(diào)控代謝重編程及重塑免疫微環(huán)境發(fā)揮抗黑色素瘤轉(zhuǎn)移的作用。通過系統(tǒng)綜述黑色素瘤的轉(zhuǎn)移過程及中藥抗黑色素瘤轉(zhuǎn)移的研究，為中藥抗黑色素瘤研究提供科學(xué)依據(jù)和理論基礎(chǔ)。

Melanoma is one of the highly metastatic tumors. The main metastatic organs are lung, lymph nodes, brain and so on. The metastasis of melanoma is closely related to epithelial-mesenchymal transition (EMT), metabolic reprogramming and immune microenvironment. EMT makes melanoma cells more invasive, accompanied by metabolic reprogramming, providing energy support for cells, promoting immune escape, and promoting tumor development and metastasis. Traditional Chinese medicine plays a role in anti-melanoma metastasis by inhibiting EMT process, regulating metabolic reprogramming and remodeling immune microenvironment. This paper systematically reviews the metastasis process of melanoma and the research progress of traditional Chinese medicine against melanoma metastasis, and provides scientific basis and theoretical basis for the study of traditional Chinese medicine against melanoma.

R285

山東中醫(yī)藥大學(xué)科學(xué)研究基金資助項(xiàng)目（KYZK2024M21）;國家自然科學(xué)基金資助項(xiàng)目（82204656）