[關鍵詞]
[摘要]
目的 研究香榧Torreya grandis的化學成分。方法 采用各種類型柱色譜及半制備液相色譜進行分離純化,經波譜數據鑒定化合物結構,MTT法檢測化合物的腫瘤細胞毒活性。結果 從香榧樹皮中分離鑒定了4個木脂素類化合物,分別為 (8R,7'S,8'R)-4,4'-二羥基-3,3',5',7'-四甲氧基木脂烷-9,9'-內酯(1)、檜脂素(2)、扁柏脂素(3)和traxillagenin(4)。結論 化合物1為新的木脂素類化合物,命名為香榧木脂素A;其余化合物均為首次從香榧中分離得到。化合物2~4在20μmol/L濃度下對HCT-116和AsPC-1癌細胞有一定的抑制作用。
[Key word]
[Abstract]
Objective To elucidate the chemical constituents of Torreya grandis var. merrillii. Methods The compounds were isolated and purified using various methods, including column chromatography and semi-preparative liquid chromatography. The structures of the isolated compounds were identified through spectral data analysis. The cytotoxic activities of these compounds were assessed using the MTT assay. Results A total of four lignan compounds were isolated, and their structures were identified as follows: (8R,7'S,8'R)-4,4'-dihydroxy-3,3',5',7'-tetramethoxy-lignane-9,9'-lactone (1), savinin (2), hinokinin (3), and traxillagenin (4). Conclusion Compound 1 is a new compound named torregrandlignan A, while the remaining compounds were isolated for the first time from T. grandis var. merrillii. Compounds 2—4 exhibited moderated cytotoxic activity against HCT-116 and AsPC-1 cells.
[中圖分類號]
R284.1
[基金項目]
國家自然科學基金資助項目(31560102);中央高?;究蒲袠I(yè)務費專項基金(ZYN2024008);科技基礎資源調查專項資助(2022FY102000)——民族醫(yī)藥疫病文獻輯錄及其防治疫病的經驗研究(2022FY102004)