目的 研究香榧Torreya grandis的化學(xué)成分。方法 采用各種類型柱色譜及半制備液相色譜進(jìn)行分離純化，經(jīng)波譜數(shù)據(jù)鑒定化合物結(jié)構(gòu)，MTT法檢測化合物的腫瘤細(xì)胞毒活性。結(jié)果 從香榧樹皮中分離鑒定了4個木脂素類化合物，分別為 (8R,7'S,8'R)-4,4'-二羥基-3,3',5',7'-四甲氧基木脂烷-9,9'-內(nèi)酯（1）、檜脂素（2）、扁柏脂素（3）和traxillagenin（4）。結(jié)論 化合物1為新的木脂素類化合物，命名為香榧木脂素A；其余化合物均為首次從香榧中分離得到?；衔?b>2～4在20μmol/L濃度下對HCT-116和AsPC-1癌細(xì)胞有一定的抑制作用。

Objective To elucidate the chemical constituents of Torreya grandis var. merrillii. Methods The compounds were isolated and purified using various methods, including column chromatography and semi-preparative liquid chromatography. The structures of the isolated compounds were identified through spectral data analysis. The cytotoxic activities of these compounds were assessed using the MTT assay. Results A total of four lignan compounds were isolated, and their structures were identified as follows: (8R,7'S,8'R)-4,4'-dihydroxy-3,3',5',7'-tetramethoxy-lignane-9,9'-lactone (1), savinin (2), hinokinin (3), and traxillagenin (4). Conclusion Compound 1 is a new compound named torregrandlignan A, while the remaining compounds were isolated for the first time from T. grandis var. merrillii. Compounds 2—4 exhibited moderated cytotoxic activity against HCT-116 and AsPC-1 cells.

R284.1

國家自然科學(xué)基金資助項(xiàng)目（31560102）;中央高?；究蒲袠I(yè)務(wù)費(fèi)專項(xiàng)基金（ZYN2024008）;科技基礎(chǔ)資源調(diào)查專項(xiàng)資助（2022FY102000）——民族醫(yī)藥疫病文獻(xiàn)輯錄及其防治疫病的經(jīng)驗(yàn)研究（2022FY102004）