特應(yīng)性皮炎（atopic dermatitis，AD）是以反復(fù)發(fā)作的濕疹樣改變伴劇烈瘙癢為特征的慢性難治性疾病，對(duì)個(gè)人和社會(huì)均已造成不同程度的疾病負(fù)擔(dān)。“腸-皮膚”軸是連接腸道與皮膚的雙向通道，腸道菌群被視為二者溝通的橋梁，在維持皮膚健康中的作用受到廣泛關(guān)注。腸道菌群失衡、腸道屏障功能受損、腸道代謝產(chǎn)物失調(diào)引起的免疫及神經(jīng)內(nèi)分泌系統(tǒng)的紊亂被視為干擾AD發(fā)生發(fā)展的關(guān)鍵因素。中醫(yī)藥對(duì)皮膚疾病的治療具有顯著優(yōu)勢(shì)，中藥復(fù)方和活性成分能夠通過(guò)調(diào)節(jié)腸道菌群達(dá)到防治AD的作用。為此，基于“腸-皮膚”軸理論，圍繞腸道菌群在AD中扮演的重要角色展開(kāi)探討，并對(duì)近年來(lái)靶向腸道菌群治療AD的中藥進(jìn)行系統(tǒng)性總結(jié)，為AD的防治提供思路與借鑒。

Atopic dermatitis (AD) is a chronic and complex disease characterized by recurrent eczematous changes with intense itching, which has caused different degrees of disease burden on both individuals and society. The “gut-skin” axis is regarded as a bidirectional channel connecting gut and skin. The gut microbiota, serving as a communication bridge between gut and skin, has attracted extensive attention for its role in maintaining skin health. It is considered that imbalance of the gut microbiota, impairment of intestinal barrier function, disorders of intestinal metabolites and disturbances in immune and neuroendocrine system are key factors interfering with the occurrence and development of AD. Traditional Chinese medicine (TCM) has notable benefits in the treatment of skin diseases. TCM compounds and active ingredients can prevent and treat AD by regulating the gut microbiota. Therefore, based on the “gut-skin” axis theory, this article explores the crucial role of the gut microbiota in AD and systematically summarizes the TCM targeting the gut microbiota for treatment of AD in recent years, with the aim of providing insights and references for prevention and treatment of AD.

R285

國(guó)家自然科學(xué)基金資助項(xiàng)目（81973846）;黑龍江省省級(jí)名中醫(yī)專(zhuān)家傳承工作室項(xiàng)目（G20191503）