癌癥是威脅人類(lèi)生命健康的主要公共衛(wèi)生問(wèn)題之一，傳統(tǒng)的化療手段藥物缺乏選擇，開(kāi)發(fā)來(lái)自于中草藥中的天然抗腫瘤成分正受到越來(lái)越多的關(guān)注。甘草是最常用的中藥材之一，甘草中的黃酮類(lèi)成分作為其主要活性成分，在現(xiàn)代研究中被報(bào)道具有廣泛的抗腫瘤活性。為進(jìn)一步明確甘草黃酮類(lèi)成分的抗腫瘤活性，該文對(duì)近十年關(guān)于甘草黃酮類(lèi)成分抗腫瘤研究進(jìn)行綜述。通過(guò)檢索PubMed、Web of Science、中國(guó)知網(wǎng)等數(shù)據(jù)庫(kù)，對(duì)甘草黃酮類(lèi)成分中具有抗腫瘤活性的主要成分及其抗腫瘤機(jī)制進(jìn)行了總結(jié)，同時(shí)綜述了甘草黃酮類(lèi)成分不同的納米遞送給藥在抗腫瘤領(lǐng)域的應(yīng)用，并對(duì)甘草黃酮類(lèi)成分的毒理機(jī)制研究進(jìn)行了梳理。結(jié)果發(fā)現(xiàn)甘草黃酮類(lèi)成分在多種類(lèi)型癌癥中具有抗癌活性，合適的納米給藥方式能增強(qiáng)甘草黃酮類(lèi)成分的抗腫瘤活性，關(guān)于甘草黃酮類(lèi)成分的毒理學(xué)研究還較少。總的來(lái)說(shuō)，甘草中的黃酮類(lèi)成分是十分具有開(kāi)發(fā)潛力的抗腫瘤天然產(chǎn)物，對(duì)甘草黃酮類(lèi)成分的納米遞送及毒理研究可能未來(lái)研究熱點(diǎn)，值得進(jìn)一步開(kāi)發(fā)研究。

Cancer represents a significant public health challenge that jeopardizes human life and well-being. Traditional chemotherapy options are limited, the development of natural anti-tumor agents derived from Chinese herbal medicine is receiving more and more attention. Licorice, one of the most frequently utilized medicinal materials in Chinese tradition, contains flavonoids that have been reported to exhibit considerable anti-tumor activity according to contemporary research. To further elucidate the anti-tumor properties of licorice flavonoids, the relevant studies conducted over the past decade are reviewed in this article. By examining databases such as PubMed, Web of Science, and China National Knowledge Infrastructure, the primary components of licorice flavonoids that possess anti-tumor activity and their corresponding mechanisms of action are summarized. Additionally, the application of nano-delivery systems for various licorice flavonoid components in drug delivery, as well as the research surrounding the toxicological mechanisms associated with these flavonoids are explored. The findings indicate that licorice flavonoids exhibit anti-cancer properties across multiple cancer types, and that appropriate nano-delivery methods can enhance their anti-tumor efficacy. However, there is a paucity of toxicological studies on licorice flavonoids. Overall, the flavonoids present in licorice are promising natural anti-tumor agents that merit further development and investigation.

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國(guó)家自然科學(xué)基金項(xiàng)目（82074397）;四川省科技創(chuàng)新苗子工程培育項(xiàng)目（MZGC20230053）;成都體育學(xué)院卓越科研計(jì)劃項(xiàng)目（ZYRC2406）