癌癥是威脅人類生命健康的主要公共衛(wèi)生問題之一，傳統(tǒng)的化療手段藥物缺乏選擇，開發(fā)來自于中草藥中的天然抗腫瘤成分正受到越來越多的關注。甘草是最常用的中藥材之一，甘草中的黃酮類成分作為其主要活性成分，在現(xiàn)代研究中被報道具有廣泛的抗腫瘤活性。為進一步明確甘草黃酮類成分的抗腫瘤活性，該文對近十年關于甘草黃酮類成分抗腫瘤研究進行綜述。通過檢索PubMed、Web of Science、中國知網(wǎng)等數(shù)據(jù)庫，對甘草黃酮類成分中具有抗腫瘤活性的主要成分及其抗腫瘤機制進行了總結，同時綜述了甘草黃酮類成分不同的納米遞送給藥在抗腫瘤領域的應用，并對甘草黃酮類成分的毒理機制研究進行了梳理。結果發(fā)現(xiàn)甘草黃酮類成分在多種類型癌癥中具有抗癌活性，合適的納米給藥方式能增強甘草黃酮類成分的抗腫瘤活性，關于甘草黃酮類成分的毒理學研究還較少?？偟膩碚f，甘草中的黃酮類成分是十分具有開發(fā)潛力的抗腫瘤天然產(chǎn)物，對甘草黃酮類成分的納米遞送及毒理研究可能未來研究熱點，值得進一步開發(fā)研究。

Cancer represents a significant public health challenge that jeopardizes human life and well-being. Traditional chemotherapy options are limited, the development of natural anti-tumor agents derived from Chinese herbal medicine is receiving more and more attention. Licorice, one of the most frequently utilized medicinal materials in Chinese tradition, contains flavonoids that have been reported to exhibit considerable anti-tumor activity according to contemporary research. To further elucidate the anti-tumor properties of licorice flavonoids, the relevant studies conducted over the past decade are reviewed in this article. By examining databases such as PubMed, Web of Science, and China National Knowledge Infrastructure, the primary components of licorice flavonoids that possess anti-tumor activity and their corresponding mechanisms of action are summarized. Additionally, the application of nano-delivery systems for various licorice flavonoid components in drug delivery, as well as the research surrounding the toxicological mechanisms associated with these flavonoids are explored. The findings indicate that licorice flavonoids exhibit anti-cancer properties across multiple cancer types, and that appropriate nano-delivery methods can enhance their anti-tumor efficacy. However, there is a paucity of toxicological studies on licorice flavonoids. Overall, the flavonoids present in licorice are promising natural anti-tumor agents that merit further development and investigation.

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國家自然科學基金項目（82074397）;四川省科技創(chuàng)新苗子工程培育項目（MZGC20230053）;成都體育學院卓越科研計劃項目（ZYRC2406）