目的 基于文獻(xiàn)計量學(xué)分析當(dāng)代外來藥物中藥化研究現(xiàn)狀，探討其發(fā)展趨勢、研究者及機構(gòu)、中藥藥性以及專利等情況。方法 在中國知網(wǎng)（CNKI）數(shù)據(jù)庫檢索外來藥物中藥化相關(guān)文獻(xiàn)及專利，并使用VOSviewer、CiteSpace、Python進(jìn)行文本挖掘，對該領(lǐng)域文獻(xiàn)年發(fā)文量、核心作者、研究機構(gòu)、研究熱點、中藥化情況及其國內(nèi)專利情況進(jìn)行可視化分析。結(jié)果 最終納入130篇符合要求的文獻(xiàn)，總發(fā)文量在2014—2024年呈上升趨勢；對31味外來中藥進(jìn)行專利檢索，檢索到相關(guān)專利4 465份。北京中醫(yī)藥大學(xué)張建軍和王林元團(tuán)隊在該領(lǐng)域具有顯著影響力，中藥藥性研究是當(dāng)前熱點，已有31味外來中藥被明確賦予中藥藥性，其藥理作用豐富且與中藥多元功效相契合，其藥性多為平、涼、寒，藥味多以苦、甘、辛為主，歸經(jīng)主要集中在肝、脾和腎經(jīng)。這些外來中藥原產(chǎn)地區(qū)廣泛，藥理作用多樣，尤其在抗炎、抗氧化、降血糖、抗腫瘤等方面展現(xiàn)出顯著效果。結(jié)論 越來越多的外來藥物被賦予中藥藥性，表明外來藥物中藥化發(fā)展趨勢良好。該領(lǐng)域研究者學(xué)術(shù)影響力尚可，專利成果豐富。未來需在此基礎(chǔ)上深化外來藥物的基礎(chǔ)研究與安全評估，拓展其在藥食同源領(lǐng)域的應(yīng)用。同時，應(yīng)借助地緣優(yōu)勢，通過搭建國際科研平臺，加強與東盟國家在傳統(tǒng)藥物方面的合作，以推動中藥現(xiàn)代化和國際化，保障中藥產(chǎn)業(yè)的可持續(xù)發(fā)展。

Objective Based on bibliometric methods, this paper analyzes the related literature on the research on introducing foreign medicines into Chinese materia medica, and discusses its research status, development trend, research members and institutions, properties of traditional Chinese medicine (TCM) and patents. Methods The literature and patents related to introduce foreign medicines into Chinese materia medica were searched in the CNKI database, and VOSviewer, CiteSpace, and Python were used for text mining to visualize the annual publication volume, core authors, research institutions, hotspots, localization as Chinese materia medica and the domestic patents. Results Finally, a total of 130 documents that met the requirements were included, and the total number of articles published showed an increasing trend from 2014 to 2024; Patents of 31 foreign Chinese materia medica were searched, and 4 465 related patents were retrieved. The team of ZHANG Jianjun and WANG Linyuan from Beijing University of Chinese Medicine has the significant influence in this field, and the research on properties of TCM is a hot spot at present. A total of 31 foreign Chinese materia medica have been explicitly endowed with properties of TCM, and their pharmacological effects are rich and consistent with the multiple effects of Chinese materia medica. Their properties are mostly neutral, cool and cold. They are mainly bitter, sweet and pungent flavour, with the liver, spleen and kidney meridians as the main meridian affinity. These foreign Chinese materia medica have a wide range of origins and diverse pharmacological effects, especially in anti-inflammatory, antioxidant, hypoglycemic and antitumor fields. Conclusion An increasing number of foreign Chinese materia medica have been endowed with properties of TCM, indicating good development trend of introducing foreign medicines into Chinese materia medica. In the future, it is necessary to deepen the fundamental research and safety assessment of foreign medicines on this basis, and expand their application in the field of medicine and food homology. Meanwhile, by taking advantage of geographical advantages, the international scientific research platforms should be built to strengthen cooperation with ASEAN countries in traditional medicine, so as to promote the modernization and internationalization of Chinese materia medica and ensure the sustainable development of Chinese medicinal industry.

G350;R282.71

中央本級重大增減支項目“名貴中藥資源可持續(xù)利用能力建設(shè)項目”（2060302）；中央本級重大增減支項目子課題“基于外來新藥用資源引入策略的兩種東盟特色藥材的系統(tǒng)研究”（QT024001）；廣西中醫(yī)藥大學(xué)“桂派中醫(yī)藥傳承創(chuàng)新團(tuán)隊”項目（2022A005）