[關鍵詞]
[摘要]
碳點(carbon dots,CDs)是一種粒徑小于10 nm的新型熒光納米粒子,中藥衍生碳點(carbon dots derived from traditional Chinese medicine,TCM-CDs)是以中藥為前驅體制備而成的CDs。與傳統CDs相比,TCM-CDs以天然中藥為前驅體,資源豐富,符合綠色化學原則;中藥中含有豐富的活性成分賦予了TCM-CDs獨特的藥理活性和生物相容性,有助于藥物遞送和靶向治療,進而可能發(fā)揮更大的藥用價值。TCM-CDs的制備過程成本低廉,適合大規(guī)模應用,進一步拓展了其在生物醫(yī)學領域的潛在價值。由此,近年來TCM-CDs得到了廣泛的關注和研究。通過詳細介紹TCM-CDs的來源、制備方法及每種制備方法的優(yōu)缺點,系統總結TCM-CDs的結構特征、性質與表征方法,全面綜述TCM-CDs在藥理活性及其機制的最新研究進展,并對TCM-CDs當前研究的局限性和未來發(fā)展方向進行了展望,以期推動TCM-CDs在傳統中醫(yī)藥領域的研究應用。
[Key word]
[Abstract]
Carbon dots (CDs) are novel fluorescent nanoparticles with a particle size of less than 10 nm. Traditional Chinese medicine (TCM)-derived carbon dots (TCM-CDs) are CDs synthesized using TCM as the precursor. Compared to conventional CDs, TCM-CDs utilize natural TCM resources, which are abundant and align with the principles of green chemistry. The rich active components in TCM endow TCM-CDs with unique pharmacological activities and enhanced biocompatibility, which can facilitate drug delivery and targeted therapy, thus potentially enhancing their medicinal value. Moreover, TCM-CDs are cost-effective to prepare, making them suitable for large-scale applications, which further expands their potential value in the biomedical field. Consequently, TCM-CDs have garnered widespread attention and interest in recent years. This review provides a detailed introduction to the sources and preparation methods of TCM-CDs, along with a discussion of the advantages and disadvantages of each preparation method. It systematically summarizes the structural features, properties, and characterization techniques of TCM-CDs, and comprehensively reviews the latest research progress on the pharmacological activities and mechanisms of TCM-CDs. The review also discusses the current limitations of TCM-CDs research and outlines future development directions, with the aim of promoting the research and application of TCM-CDs in the field of TCM.
[中圖分類號]
R283.3
[基金項目]
江西省研究生創(chuàng)新專項項目(YC2024-B221);江西中醫(yī)藥大學校級科技創(chuàng)新團隊發(fā)展計劃(CXTD22007)