肺纖維化是一種慢性間質(zhì)性肺疾病的末期表現(xiàn)，預(yù)后極差，嚴(yán)重影響患者的生活質(zhì)量。上皮-間充質(zhì)轉(zhuǎn)化（epithelial-mesenchymal transition，EMT）過程的激活作為肺纖維化的發(fā)病機(jī)制之一，在肺纖維化病理過程中具有重要作用。研究表明，中藥單味藥、活性成分及其復(fù)方制劑在改善纖維化癥狀和延緩疾病進(jìn)程方面具有顯著效果，其作用機(jī)制與直接或間接抑制EMT密切相關(guān)。因此，通過對中藥抑制EMT干預(yù)肺纖維化進(jìn)行綜述，為臨床肺纖維化的治療提供參考。

Pulmonary fibrosis (PF) is a late-stage manifestation of chronic interstitial lung disease characterized by an extremely poor prognosis, significantly impacting the quality of life for patients. Activation of the epithelial-mesenchymal transition (EMT) process, as one of the pathogenic mechanisms of pulmonary fibrosis, plays an important role in the pathological process of pulmonary fibrosis. Studies have shown that single herbs, active ingredients and their compound preparations have significant effects in improving fibrosis symptoms and delaying the disease process. The mechanism of action is closely linked to the direct or indirect inhibition of EMT. This finding underscores the importance of inhibiting EMT as a crucial component of traditional Chinese medicine (TCM) in treatment of pulmonary fibrosis. Therefore, this article reviews the research on the role of TCM in inhibiting EMT in pulmonary fibrosis, aiming to provide a reference for the clinical treatment of this condition.

R285

國家自然科學(xué)基金重點(diǎn)項(xiàng)目（U21A20406）；安徽省科技重大專項(xiàng)（202303a07020007）