隨著全球人口老齡化的加劇，神經退行性疾?。╪eurodegenerative diseases，NDDs）的發(fā)病率逐年遞增，已成為嚴重影響人類生活質量的公共衛(wèi)生難題，因其發(fā)病機制的復雜性及神經退變的不可逆性，目前尚無有效治愈手段。近年來，隨著小檗堿及其衍生物的藥理研究不斷深入，發(fā)現(xiàn)其具有抑制神經炎癥、抗氧化應激、修復神經元損傷、維持血腦屏障穩(wěn)定等作用，在NDDs防治方面顯示出極大潛力。通過對2015—2025年涉及小檗堿及其衍生物治療NDDs的研究文獻進行歸納，系統(tǒng)總結了小檗堿及其衍生物對阿爾茨海默病、帕金森病、亨廷頓病、多發(fā)性硬化、肌萎縮性側索硬化的干預機制及應用，為小檗堿及其衍生物用于神經系統(tǒng)疾病提供參考。

With the aggravation of global population aging, the incidence of neurodegenerative diseases (NDDs) has been increasing year by year, and has become a public health problem that seriously affects the quality of life of human beings. Due to the complexity of its pathogenesis and the irreversibility of its neurodegeneration, there is no effective cure for it yet. In recent years, as the pharmacological studies of berberine and its derivatives have been deepened, it has been found to have multiple effects such as inhibiting neuroinflammation, anti-oxidative stress, repairing neuronal damage, and maintaining the stability of the blood-brain barrier, which shows great potential in prevention and treatment of NDDs. Based on this, this paper systematically summarizes the intervention mechanism and application of berberine and its derivatives in Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, multiple sclerosis, and amyotrophic lateral sclerosis by summarizing the research literature involving berberine and its derivatives in treatment of NDDs from 2015 to 2025, with a view to providing references to berberine and its derivatives in their application to neurological diseases.

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國家重點研發(fā)計劃資助項目（2022YFC3501103）；2024年河南省科技攻關項目（242102311277）；2023年度河南省“雙一流”創(chuàng)建學科中醫(yī)學科研專項課題（HSRP-DFCTCM-2023-2-18）；河南省中醫(yī)藥傳承與創(chuàng)新人才工程（仲景工程）中醫(yī)藥學科領軍人才（豫衛(wèi)中醫(yī)函[2020]8號）