抑郁癥作為一種多維度病理異質(zhì)性疾病，其病理機制與線粒體功能障礙引發(fā)的能量代謝紊亂密切相關(guān)，尤見疲勞、動力缺失等核心癥狀。中醫(yī)認為“郁證”本質(zhì)在于五臟氣機失調(diào)，而現(xiàn)代研究發(fā)現(xiàn)，線粒體作為細胞能量樞紐，其質(zhì)量控制系統(tǒng)（mitochondrial quality control system，MQCS）主導的“能量代謝-氧化還原-免疫穩(wěn)態(tài)”級聯(lián)反應(yīng)，與中醫(yī)“氣”的功能高度契合。MQCS失衡會破壞“氣血-臟腑-神志”動態(tài)平衡，從而在分子層面闡釋“氣機失調(diào)”致郁的病理基礎(chǔ)，為“調(diào)和五臟”抗抑郁治則提供科學依據(jù)。通過整合多源數(shù)據(jù)庫，應(yīng)用CiteSpace軟件與系統(tǒng)藥理學方法，構(gòu)建MQCS動態(tài)監(jiān)測體系，解析中藥復方調(diào)控線粒體功能的時空網(wǎng)絡(luò)作用，揭示其多級聯(lián)反應(yīng)機制。創(chuàng)新性地將中醫(yī)抽象思維轉(zhuǎn)化為可量化的參數(shù)體系，搭建了從“宏觀辨證”到“微觀適配”的轉(zhuǎn)化橋梁，為精準醫(yī)學框架下的個體化診療提供可操作化的方法學基礎(chǔ)，同時為中西醫(yī)整合醫(yī)學的迭代升級奠定理論基石。

Depression is a multi-dimensional pathological heterogeneous disease. The pathological mechanism of depression closely relates to the disorder of energy metabolism that caused by mitochondrial dysfunction, especially in core symptoms such as fatigue, lack of motivation, etc. In traditional Chinese medicine (TCM) theory, it believes that the essence of ‘depression syndrome’ lies in the dysregulation of qi movement of Five Zang organs. Modern researches have demonstrated that mitochondrion serves as the energy hub of cells, and its “energy metabolism-redox-immune homeostasis” cascade reaction that led by mitochondrial quality control system (MQCS) is highly consistent with the function of qi in TCM theory. The imbalance of MQCS destroys the dynamic balance of “qi-blood-Zang-Fu organs-mental activity”, explaining the pathological basis of depression that caused by “dysregulation of qi movement” at the molecular level, and providing scientific evidence for anti-depression treatment principle of “harmonizing the five internal organs”. By integrating multi-source databases, applying CiteSpace software and systems pharmacology methods to construct the MQCS dynamic monitoring system and analyze the spatio-temporal network functions of TCM prescriptions in regulating mitochondrial functions, and reveal its multi-cascade reaction mechanisms. It innovatively transforms the abstract thinking of TCM into a quantifiable parameter system. A transformation bridge from “macro syndrome differentiation”to “micro adaptation”, providing an operable methodological basis for individualized diagnosis and treatments under the framework of precision medicines, and laying a theoretical foundation for the iterative upgrading of integrated Chinese and Western medicines.

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國家自然科學基金資助項目（82274360）；山西省中醫(yī)藥管理局資助項目（2024ZYY2A032）；2022年度山西省基礎(chǔ)研究計劃（自由探索類）項目（202203021221030）；山西省回國留學人員科研資助項目（2022-026）；山西省中醫(yī)藥創(chuàng)新團隊（zyytd2024020）